The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes
KM Gillespie, SC Bain, AH Barnett, PJ Bingley… - The Lancet, 2004 - thelancet.com
KM Gillespie, SC Bain, AH Barnett, PJ Bingley, MR Christie, GV Gill, EAM Gale
The Lancet, 2004•thelancet.comThe incidence of childhood type 1 diabetes has risen over the past 50 years. We compared
the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago
and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002.
The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p= 0·
003), especially in those diagnosed at age 5 years or younger, which is consistent with the
hypothesis that the rise of type 1 diabetes is due to a major environmental effect.
the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago
and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002.
The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p= 0·
003), especially in those diagnosed at age 5 years or younger, which is consistent with the
hypothesis that the rise of type 1 diabetes is due to a major environmental effect.
Summary
The incidence of childhood type 1 diabetes has risen over the past 50 years. We compared the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002. The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p=0·003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect.
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