Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells
HC Maisey, M Hensler, V Nizet, KS Doran - 2007 - Am Soc Microbiol
HC Maisey, M Hensler, V Nizet, KS Doran
2007•Am Soc MicrobiolSurface filamentous structures known as pili have been discovered recently in the gram-
positive streptococcal pathogens that cause invasive disease in humans, including group B
Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded
by pilA and pilB, also facilitate the interaction of this important agent of central nervous
system infection with endothelial cells of the human blood-brain barrier.
positive streptococcal pathogens that cause invasive disease in humans, including group B
Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded
by pilA and pilB, also facilitate the interaction of this important agent of central nervous
system infection with endothelial cells of the human blood-brain barrier.
Abstract
Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB, also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.
American Society for Microbiology