Recent progress concerning CpG DNA and its use as a vaccine adjuvant

H Shirota, DM Klinman - Expert review of vaccines, 2014 - Taylor & Francis
H Shirota, DM Klinman
Expert review of vaccines, 2014Taylor & Francis
CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides designed to
specifically agonize Toll-like receptor 9. Here, we review recent progress in understanding
the mechanism of action of CpG ODN and provide an overview of human clinical trial results
using CpG ODN to improve the vaccines for cancer, allergy and infectious disease.
CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides designed to specifically agonize Toll-like receptor 9. Here, we review recent progress in understanding the mechanism of action of CpG ODN and provide an overview of human clinical trial results using CpG ODN to improve the vaccines for cancer, allergy and infectious disease.
Taylor & Francis Online