[HTML][HTML] Allocation of helper T-cell epitope immunodominance according to three-dimensional structure in the human immunodeficiency virus type I envelope …
G Dai, NK Steede, SJ Landry - Journal of Biological Chemistry, 2001 - ASBMB
The specificity and intensity of CD4+ helper T-cell responses determine the effectiveness of
immune effector functions. Promiscuously immunodominant helper T-cell epitopes in the
human immunodeficiency virus (HIV) envelope glycoprotein gp120 could be important in the
development of broadly protective immunity, but the underlying mechanisms of
immunodominance and promiscuity remain poorly defined. In this study, gp120 helper T-cell
epitopes were systematically mapped in CBA/J and BALB/c mice by restimulation assays …
immune effector functions. Promiscuously immunodominant helper T-cell epitopes in the
human immunodeficiency virus (HIV) envelope glycoprotein gp120 could be important in the
development of broadly protective immunity, but the underlying mechanisms of
immunodominance and promiscuity remain poorly defined. In this study, gp120 helper T-cell
epitopes were systematically mapped in CBA/J and BALB/c mice by restimulation assays …