Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus—analyses of strain, gender, and age effects
RW McMurray, RW Hoffman, W Nelson… - Clinical immunology and …, 1997 - Elsevier
To gain a better understanding of inherent gender-related effects on autoimmunity, cytokine
genes were examined in female and male New Zealand Black X New Zealand White (B/W)
mice, which are a murine model of systemic lupus erythematosus (SLE). In preliminary
studies, semiquantitative reverse transcriptase–polymerase chain reaction analysis showed
a trend for B/W spleen cell interferon γ (IFN-γ) mRNA in B/W female spleen cells to exceed
that of males. This difference was obliterated following concanavalin A (Con A) stimulation …
genes were examined in female and male New Zealand Black X New Zealand White (B/W)
mice, which are a murine model of systemic lupus erythematosus (SLE). In preliminary
studies, semiquantitative reverse transcriptase–polymerase chain reaction analysis showed
a trend for B/W spleen cell interferon γ (IFN-γ) mRNA in B/W female spleen cells to exceed
that of males. This difference was obliterated following concanavalin A (Con A) stimulation …