[HTML][HTML] Natural CD8+ CD122+ T cells are more potent in suppression of allograft rejection than CD4+ CD25+ regulatory T cells
Z Dai, S Zhang, Q Xie, S Wu, J Su, S Li, Y Xu… - American Journal of …, 2014 - Elsevier
Despite extensive studies on CD4+ CD25+ regulatory T cells (Tregs), their application in
adoptive transfer therapies is still not optimal in immune-competent wild-type (WT) animal
models. Therefore, it is compelling to search for more potent Tregs for potential clinical
application. Mounting evidence has shown that naturally occurring CD8+ CD122+ T cells
are also Tregs. However, their suppression in allograft rejection, efficiency in suppression
and underlying mechanisms remain unclear. Using a murine allotransplantation model, we …
adoptive transfer therapies is still not optimal in immune-competent wild-type (WT) animal
models. Therefore, it is compelling to search for more potent Tregs for potential clinical
application. Mounting evidence has shown that naturally occurring CD8+ CD122+ T cells
are also Tregs. However, their suppression in allograft rejection, efficiency in suppression
and underlying mechanisms remain unclear. Using a murine allotransplantation model, we …