Marked developmental changes in heme oxygenase-1 (HO-1) expression in the mouse placenta: correlation between HO-1 expression and placental development
S Watanabe, R Akagi, M Mori, T Tsuchiya, S Sassa - Placenta, 2004 - Elsevier
Heme catabolism during embryonic period is not well understood. It has been suggested
that placental heme oxygenase (HO)-1, which is an inducible isoform of the rate-limiting
enzyme in the heme degradation pathway, may be involved in supporting normal fetal
development. In this study, we examined the distribution of HO-1 protein in the developing
mouse embryo, as well as developmental changes of ho-1 gene expression, and the
enzyme activity of HO and biliverdin IXα reductase (BVR-A) in placenta. Ectoplacental cone …
that placental heme oxygenase (HO)-1, which is an inducible isoform of the rate-limiting
enzyme in the heme degradation pathway, may be involved in supporting normal fetal
development. In this study, we examined the distribution of HO-1 protein in the developing
mouse embryo, as well as developmental changes of ho-1 gene expression, and the
enzyme activity of HO and biliverdin IXα reductase (BVR-A) in placenta. Ectoplacental cone …