Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
MF Lyon - nature, 1961 - nature.com
MF Lyon
nature, 1961•nature.comOhno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma
cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyknotic.
They interpreted this chromosome as an X-chromosome and suggested that the so-called
sex chromatin was composed of one heteropyknotic X-chromosome. They left open the
question whether the heteropyknosis was shown by the paternal X-chromosome only, or the
chromosome from either parent indifferently.
cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyknotic.
They interpreted this chromosome as an X-chromosome and suggested that the so-called
sex chromatin was composed of one heteropyknotic X-chromosome. They left open the
question whether the heteropyknosis was shown by the paternal X-chromosome only, or the
chromosome from either parent indifferently.
Abstract
Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyknotic. They interpreted this chromosome as an X-chromosome and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome. They left open the question whether the heteropyknosis was shown by the paternal X-chromosome only, or the chromosome from either parent indifferently.
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