Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus
Females of child-bearing age are more resistant to infectious disease and have an
increased risk of systemic lupus erythematosus (SLE). We hypothesized that estrogen-
induced gene expression could establish an immunoactivated state which would render
enhanced defense against infection, but may be deleterious in autoimmune development.
Using peripheral blood mononuclear cells (PBMCs), we demonstrate enhanced responses
with immunogen stimulation in the presence of 17β-estradiol (E2) and gene array analyses …
increased risk of systemic lupus erythematosus (SLE). We hypothesized that estrogen-
induced gene expression could establish an immunoactivated state which would render
enhanced defense against infection, but may be deleterious in autoimmune development.
Using peripheral blood mononuclear cells (PBMCs), we demonstrate enhanced responses
with immunogen stimulation in the presence of 17β-estradiol (E2) and gene array analyses …