Effects of estrogen receptor subtype-selective agonists on autoimmune disease in lupus-prone NZB/NZW F1 mouse model
J Li, RW McMurray - Clinical immunology, 2007 - Elsevier
The specific roles of estrogen receptor (ER) subtypes α and β in mediating estrogen's
influences on lupus autoimmunity are unknown. Herein we found that ovariectomized
NZB/NZW F1 mice treated with propyl pyrazole triol (ERα-selective agonist) had significantly
shorter survival, earlier development of albuminuria, higher serum concentrations of total
IgG and prolactin, increased serum levels of anti-DNA IgG3, IgG2a and IgG2b and
decreased anti-DNA IgG1 level compared to vehicle controls. In contrast, diarylpropionitrile …
influences on lupus autoimmunity are unknown. Herein we found that ovariectomized
NZB/NZW F1 mice treated with propyl pyrazole triol (ERα-selective agonist) had significantly
shorter survival, earlier development of albuminuria, higher serum concentrations of total
IgG and prolactin, increased serum levels of anti-DNA IgG3, IgG2a and IgG2b and
decreased anti-DNA IgG1 level compared to vehicle controls. In contrast, diarylpropionitrile …