[HTML][HTML] The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation

J Lugassy, S Zaffryar-Eilot, S Soueid, A Mordoviz… - Journal of Biological …, 2012 - ASBMB
Lysyl oxidase-like-2 (LOXL2) induces tumor progression and fibrosis. It also inhibits the
differentiation of keratinocytes promoting development of squamous cell carcinomas.
Stimulation of HaCaT skin keratinocytes with exogenous LOXL2 or overexpression of
LOXL2 in these cells inhibits their differentiation as manifested by inhibition of calcium or
vitamin D-induced involucrin expression. The inhibition was abrogated by the LOXL2
function-blocking monoclonal antibody AB0023 as well as by an anti-LOXL2 polyclonal …