Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors
H Kaphzan, P Hernandez, JI Jung, KK Cowansage… - Biological …, 2012 - Elsevier
BACKGROUND: Angelman syndrome (AS) is a human neuropsychiatric disorder associated
with autism, mental retardation, motor abnormalities, and epilepsy. In most cases, AS is
caused by the deletion of the maternal copy of UBE3A gene, which encodes the enzyme
ubiquitin ligase E3A, also termed E6-AP. A mouse model of AS has been generated and
these mice exhibit many of the observed neurological alterations in humans. Because of
clinical and neuroanatomical similarities between AS and schizophrenia, we examined AS …
with autism, mental retardation, motor abnormalities, and epilepsy. In most cases, AS is
caused by the deletion of the maternal copy of UBE3A gene, which encodes the enzyme
ubiquitin ligase E3A, also termed E6-AP. A mouse model of AS has been generated and
these mice exhibit many of the observed neurological alterations in humans. Because of
clinical and neuroanatomical similarities between AS and schizophrenia, we examined AS …