Bile duct epithelial cells (ie, cholangiocytes), which line the intrahepatic biliary epithelium,
are the target cells in a number of human cholestatic liver diseases (termed
cholangiopathies). Cholangiocyte proliferation and death is present in virtually all human
cholangiopathies. A number of recent studies have provided insights into the key
mechanisms that regulate the proliferation and function of cholangiocytes during the
pathogenesis of cholestatic liver diseases. In our review, we have summarised the most …