[HTML][HTML] Identification of a novel integrin αvβ3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells
N Chen, SJ Leu, V Todorovic, SCT Lam… - Journal of Biological …, 2004 - ASBMB
CCN1 (CYR61) is a matricellular inducer of angiogenesis essential for successful vascular
development. Though devoid of the canonical RGD sequence motif recognized by some
integrins, CCN1 binds to, and functions through integrin α v β 3 to promote pro-angiogenic
activities in activated endothelial cells. In this study we identify a 20-residue sequence, V2 (
NCKHQCTCIDGAVGCIPLCP), in domain II of CCN1 as a novel binding site for integrin α v β
3. Immobilized synthetic V2 peptide supports α v β 3-mediated cell adhesion; soluble V2 …
development. Though devoid of the canonical RGD sequence motif recognized by some
integrins, CCN1 binds to, and functions through integrin α v β 3 to promote pro-angiogenic
activities in activated endothelial cells. In this study we identify a 20-residue sequence, V2 (
NCKHQCTCIDGAVGCIPLCP), in domain II of CCN1 as a novel binding site for integrin α v β
3. Immobilized synthetic V2 peptide supports α v β 3-mediated cell adhesion; soluble V2 …