[HTML][HTML] Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins αvβ3 and α6β1 in human umbilical vein endothelial cells
SJ Leu, SCT Lam, LF Lau - Journal of Biological Chemistry, 2002 - ASBMB
CYR61 (CCN1) is an extracellular matrix-associated protein of the CCN family, which also
includes CTGF (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 (CCN5), and WISP-3
(CCN6). Purified CYR61 induces neovascularization in corneal implants, and Cyr61-null
mice suffer embryonic death due to vascular defects, thus establishing that CYR61 is an
important regulator of angiogenesis. Aberrant expression ofCyr61 is associated with breast
cancer, wound healing, and vascular diseases such as atherosclerosis and restenosis. In …
includes CTGF (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 (CCN5), and WISP-3
(CCN6). Purified CYR61 induces neovascularization in corneal implants, and Cyr61-null
mice suffer embryonic death due to vascular defects, thus establishing that CYR61 is an
important regulator of angiogenesis. Aberrant expression ofCyr61 is associated with breast
cancer, wound healing, and vascular diseases such as atherosclerosis and restenosis. In …