[HTML][HTML] TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia
O Kosmider, V Gelsi-Boyer, M Ciudad, C Racoeur… - …, 2009 - ncbi.nlm.nih.gov
Haematologica, 2009•ncbi.nlm.nih.gov
Background Acquired somatic deletions and loss-of-function mutations in one or several
codons of the TET2 (Ten-Eleven Translocation-2) gene were recently identified in
hematopoietic cells from patients with myeloid malignancies, including myeloproliferative
disorders and myelodysplastic syndromes. The present study was designed to determine
the prevalence of TET2 gene alterations in chronic myelomonocytic leukemias.
codons of the TET2 (Ten-Eleven Translocation-2) gene were recently identified in
hematopoietic cells from patients with myeloid malignancies, including myeloproliferative
disorders and myelodysplastic syndromes. The present study was designed to determine
the prevalence of TET2 gene alterations in chronic myelomonocytic leukemias.
Background
Acquired somatic deletions and loss-of-function mutations in one or several codons of the TET2 (Ten-Eleven Translocation-2) gene were recently identified in hematopoietic cells from patients with myeloid malignancies, including myeloproliferative disorders and myelodysplastic syndromes. The present study was designed to determine the prevalence of TET2 gene alterations in chronic myelomonocytic leukemias.
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