[HTML][HTML] Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo
The role of insulin-like growth factor-binding protein (IGFBP)-5 in human breast cancer cell
growth is unclear. We determined the effects of IGFBP-5 expression on the growth of human
breast cancer cell lines in vivo and in vitro. Expression of IGFBP-5, both by stable
transfection and adenoviral-mediated infection, was inhibitory to the growth of MDA-MB-231
and Hs578T human breast cancer cells over a 13-day period. IGFBP-5 expression resulted
in a G 2/M cell cycle arrest and the induction of apoptosis in both cell lines, an effect that was …
growth is unclear. We determined the effects of IGFBP-5 expression on the growth of human
breast cancer cell lines in vivo and in vitro. Expression of IGFBP-5, both by stable
transfection and adenoviral-mediated infection, was inhibitory to the growth of MDA-MB-231
and Hs578T human breast cancer cells over a 13-day period. IGFBP-5 expression resulted
in a G 2/M cell cycle arrest and the induction of apoptosis in both cell lines, an effect that was …