Retinol dehydrogenases (RDHs) in the visual cycle
RO Parker, RK Crouch - Experimental eye research, 2010 - Elsevier
The isomerization of 11-cis retinal to all-trans retinal in photoreceptors is the first step in
vision. For photoreceptors to function in constant light, the all-trans retinal must be converted
back to 11-cis retinal via the enzymatic steps of the visual cycle. Within this cycle, all-trans
retinal is reduced to all-trans retinol in photoreceptors and transported to the retinal pigment
epithelium (RPE). In the RPE, all-trans retinol is converted to 11-cis retinol, and in the final
enzymatic step, 11-cis retinol is oxidized to 11-cis retinal. The first and last steps of the …
vision. For photoreceptors to function in constant light, the all-trans retinal must be converted
back to 11-cis retinal via the enzymatic steps of the visual cycle. Within this cycle, all-trans
retinal is reduced to all-trans retinol in photoreceptors and transported to the retinal pigment
epithelium (RPE). In the RPE, all-trans retinol is converted to 11-cis retinol, and in the final
enzymatic step, 11-cis retinol is oxidized to 11-cis retinal. The first and last steps of the …