Dry age-related macular degeneration: A currently unmet clinical need

JF Girmens, JA Sahel, K Marazova - Intractable & rare diseases …, 2012 - jstage.jst.go.jp
JF Girmens, JA Sahel, K Marazova
Intractable & rare diseases research, 2012jstage.jst.go.jp
Age-related macular degeneration (AMD) is a leading cause of severe visual impairment
and disability in older people worldwide. Although considerable advances in the
management of the neovascular form of AMD have been made in the last decade, no
therapy is yet available for the advanced dry form of AMD (geographic atrophy). This review
focuses on current trends in the development of new therapies targeting specific
pathophysiological pathways of dry AMD. Increased understanding of the complex …
Summary
Age-related macular degeneration (AMD) is a leading cause of severe visual impairment and disability in older people worldwide. Although considerable advances in the management of the neovascular form of AMD have been made in the last decade, no therapy is yet available for the advanced dry form of AMD (geographic atrophy). This review focuses on current trends in the development of new therapies targeting specific pathophysiological pathways of dry AMD. Increased understanding of the complex mechanisms that underlie dry AMD will help to address this largely unmet clinical need.
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