[HTML][HTML] Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo

FJ Naya, B Mercer, J Shelton, JA Richardson… - Journal of Biological …, 2000 - ASBMB
Adult skeletal muscle fibers can be categorized into fast and slow twitch subtypes based on
specialized contractile and metabolic properties and on distinctive patterns of muscle gene
expression. Muscle fiber-type characteristics are dependent on the frequency of motor nerve
stimulation and are thought to be controlled by calcium-dependent signaling. The calcium,
calmodulin-dependent protein phosphatase, calcineurin, stimulates slow fiber-specific gene
promoters in cultured skeletal muscle cells, and the calcineurin inhibitor, cyclosporin A …