[HTML][HTML] Life in the fast lane: mammalian disease models in the genomics era

LE Dow, SW Lowe - Cell, 2012 - cell.com
LE Dow, SW Lowe
Cell, 2012cell.com
Analyses of the human genome have proven extremely successful in identifying changes
that contribute to human disease. Genetically engineered mice provide a powerful tool to
analyze these changes, although they are slow and costly and do not always recapitulate
human biology. Recent advances in genomic technologies, rodent-modeling approaches,
and the production of patient-derived reprogrammed cell lines now provide a plethora of
complementary systems to study disease states and test new therapies. Continued evolution …
Analyses of the human genome have proven extremely successful in identifying changes that contribute to human disease. Genetically engineered mice provide a powerful tool to analyze these changes, although they are slow and costly and do not always recapitulate human biology. Recent advances in genomic technologies, rodent-modeling approaches, and the production of patient-derived reprogrammed cell lines now provide a plethora of complementary systems to study disease states and test new therapies. Continued evolution and integration of these model systems will be the key to realizing the benefits of the genomic revolution and refining our understanding and treatment of human diseases.
cell.com