Deep‐tissue photoacoustic tomography of a genetically encoded near‐infrared fluorescent probe
Angewandte Chemie International Edition, 2012•Wiley Online Library
Skin‐deep: The combination of a near‐infrared fluorescent protein (iRFP) and deep‐tissue
photoacoustic tomography clearly demonstrates the superiority of iRFP over other
genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was
obtained at a depth of 4 mm in a live animal, and volumetric images of a tumor were
produced (see image), thus allowing the spatially resolved monitoring of its development.
photoacoustic tomography clearly demonstrates the superiority of iRFP over other
genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was
obtained at a depth of 4 mm in a live animal, and volumetric images of a tumor were
produced (see image), thus allowing the spatially resolved monitoring of its development.
Abstract
Skin‐deep: The combination of a near‐infrared fluorescent protein (iRFP) and deep‐tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4 mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.
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