MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults
W Shen, J Chen, M Gantz, M Punyanitya… - European journal of …, 2012 - nature.com
W Shen, J Chen, M Gantz, M Punyanitya, SB Heymsfield, D Gallagher, J Albu, E Engelson…
European journal of clinical nutrition, 2012•nature.comRESULTS: An inverse correlation was observed between pelvic BMAT and pelvic, total and
spine BMD in the younger PBM group (r=− 0.419 to− 0.461, P< 0.001) and in the older PoBL
group (r=− 0.405 to− 0.500, P< 0.001). After adjusting for age, sex, ethnicity, menopausal
status, total body fat, skeletal muscle, subcutaneous and visceral adipose tissue, neither
subject group (younger PBM vs older PoBL) nor its interaction with pelvic BMAT significantly
contributed to the regression models with BMD as dependent variable and pelvic BMAT as …
spine BMD in the younger PBM group (r=− 0.419 to− 0.461, P< 0.001) and in the older PoBL
group (r=− 0.405 to− 0.500, P< 0.001). After adjusting for age, sex, ethnicity, menopausal
status, total body fat, skeletal muscle, subcutaneous and visceral adipose tissue, neither
subject group (younger PBM vs older PoBL) nor its interaction with pelvic BMAT significantly
contributed to the regression models with BMD as dependent variable and pelvic BMAT as …
RESULTS:
An inverse correlation was observed between pelvic BMAT and pelvic, total and spine BMD in the younger PBM group (r=− 0.419 to− 0.461, P< 0.001) and in the older PoBL group (r=− 0.405 to− 0.500, P< 0.001). After adjusting for age, sex, ethnicity, menopausal status, total body fat, skeletal muscle, subcutaneous and visceral adipose tissue, neither subject group (younger PBM vs older PoBL) nor its interaction with pelvic BMAT significantly contributed to the regression models with BMD as dependent variable and pelvic BMAT as independent variable (P= 0.434–0.928).
CONCLUSIONS:
Our findings indicate that an inverse relationship between pelvic BMAT and BMD is present both in younger subjects who have not yet experienced bone loss and also in older subjects. These results provide support at the macro-imaging level for the hypothesis that low BMD may be a result of preferential differentiation of mesenchymal stem cells from osteoblasts to adipocytes.
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