[HTML][HTML] S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity
DC Montrose, EJ Scherl, BP Bosworth, XK Zhou… - Journal of lipid …, 2013 - ASBMB
Signaling through sphingosine-1-phosphate receptor 1 (S1P 1) promotes blood vessel
barrier function. Degradation of S1P 1 results in increased vascular permeability in the lung
and may explain side effects associated with administration of FTY720, a functional
antagonist of the S1P 1 receptor that is currently used to treat multiple sclerosis. Ulcerative
colitis (UC) is characterized by an increased density of abnormal vessels. The expression or
role of S1P 1 in blood vessels in the colon has not been investigated. In the present study …
barrier function. Degradation of S1P 1 results in increased vascular permeability in the lung
and may explain side effects associated with administration of FTY720, a functional
antagonist of the S1P 1 receptor that is currently used to treat multiple sclerosis. Ulcerative
colitis (UC) is characterized by an increased density of abnormal vessels. The expression or
role of S1P 1 in blood vessels in the colon has not been investigated. In the present study …