[HTML][HTML] Generation of a new form of human PrPSc in vitro by interspecies transmission from cervid prions
MA Barria, GC Telling, P Gambetti, JA Mastrianni… - Journal of Biological …, 2011 - ASBMB
Prion diseases are infectious neurodegenerative disorders that affect humans and animals
and that result from the conversion of normal prion protein (PrP C) into the misfolded prion
protein (PrP Sc). Chronic wasting disease (CWD) is a prion disorder of increasing
prevalence within the United States that affects a large population of wild and captive deer
and elk. Determining the risk of transmission of CWD to humans is of utmost importance,
considering that people can be infected by animal prions, resulting in new fatal diseases. To …
and that result from the conversion of normal prion protein (PrP C) into the misfolded prion
protein (PrP Sc). Chronic wasting disease (CWD) is a prion disorder of increasing
prevalence within the United States that affects a large population of wild and captive deer
and elk. Determining the risk of transmission of CWD to humans is of utmost importance,
considering that people can be infected by animal prions, resulting in new fatal diseases. To …