[HTML][HTML] Latent transforming growth factor-β (TGF-β) binding proteins: orchestrators of TGF-β availability
DB Rifkin - Journal of Biological Chemistry, 2005 - ASBMB
The latent transforming growth factor-ß (TGF-ß) 1 binding proteins (LTBP-1–4) are secreted
multidomain glycoproteins, three of which are central to TGF-ß regulation (1, 2). LTBP-1 is a
component of the latent TGF-ß complex that consists of TGF-ß, the TGF-ß propeptide, and
LTBP (Fig. 1)(3). TGF-ß is synthesized as a homodimeric proprotein, and the dimeric
propeptide is cleaved intracellularly from the growth factor (4). Unlike most propeptides that
have little affinity for the mature protein, the TGF-ß propeptide strongly binds to TGF-ß, and …
multidomain glycoproteins, three of which are central to TGF-ß regulation (1, 2). LTBP-1 is a
component of the latent TGF-ß complex that consists of TGF-ß, the TGF-ß propeptide, and
LTBP (Fig. 1)(3). TGF-ß is synthesized as a homodimeric proprotein, and the dimeric
propeptide is cleaved intracellularly from the growth factor (4). Unlike most propeptides that
have little affinity for the mature protein, the TGF-ß propeptide strongly binds to TGF-ß, and …