[HTML][HTML] p53 lesions in leukemic transformation

A Harutyunyan, T Klampfl, M Cazzola… - New England Journal …, 2011 - Mass Medical Soc
New England Journal of Medicine, 2011Mass Medical Soc
To the Editor: Myeloproliferative neoplasms have an inherent tendency toward leukemic
transformation. The genetic mechanisms of transformation remain largely unknown. We
analyzed biopsy specimens of myeloproliferative neoplastic tissue from 330 patients for
chromosomal aberrations associated with leukemic transformation (the analysis was
performed with the use of Genome-Wide Human SNP [single-nucleotide polymorphism]
Array, Affymetrix). Of those patients, 308 had chronic-phase myeloproliferative neoplasms …
To the Editor: Myeloproliferative neoplasms have an inherent tendency toward leukemic transformation. The genetic mechanisms of transformation remain largely unknown. We analyzed biopsy specimens of myeloproliferative neoplastic tissue from 330 patients for chromosomal aberrations associated with leukemic transformation (the analysis was performed with the use of Genome-Wide Human SNP [single-nucleotide polymorphism] Array, Affymetrix). Of those patients, 308 had chronic-phase myeloproliferative neoplasms and 22 had postmyeloproliferative-phase neoplasm secondary acute myeloid leukemia (AML). Among these 22 patients, 1 carried the myeloproliferative leukemia virus oncogene (MPL) W515L and all others carried the Janus kinase 2 gene (JAK2) V617F mutation. . . .
The New England Journal Of Medicine