[HTML][HTML] Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells

T Nakano, A Katafuchi, M Matsubara, H Terato… - Journal of biological …, 2009 - ASBMB
DNA-protein cross-links (DPCs) are unique among DNA lesions in their unusually bulky
nature. The steric hindrance imposed by cross-linked proteins (CLPs) will hamper DNA
transactions, such as replication and transcription, posing an enormous threat to cells. In
bacteria, DPCs with small CLPs are eliminated by nucleotide excision repair (NER),
whereas oversized DPCs are processed exclusively by RecBCD-dependent homologous
recombination (HR). Here we have assessed the roles of NER and HR for DPCs in …