Pressures and flows were measured in surface glomerular capillaries, efferent arterioles,
and proximal tubules of 22 Wistar rats in the early autologous phase of nephrotoxic serum
nephritis (NSN). Linear deposits of rabbit and rat IgG and C3 component of complement
were demonstrated in glomerular capillary walls by immunofluorescence microscopy. Light
microscopy revealed diffuse proliferative glomerulonephritis, and proteinuria was present.
Although whole kidney and single nephron glomerular filtration rate (GFR) in NSN (0.8 plus …

Micropuncture techniques were used to evaluate the determinants of glomerular filtration in
hydropenic dogs. Stop-flow and servo-null techniques were used to estimate the glomerular
capillary and proximal tubule hydrostatic pressures. The validity of stop-flow estimates was
verified by comparisons with direct puncture of glomerular capillaries in Munich-Wistar rats.
Efferent arteriolar oncotic pressure was calculated from the filtration fraction and systemic
protein concentrations. This calculation was verified in separate experiments by …