AT‐helper cell epitope overlaps a major B‐cell epitope in human papillomavirus type 18 E2 protein
M LEHTINEN, G STELLATO, H HYÖTY, P NIEMINEN… - APMIS, 1992 - Wiley Online Library
M LEHTINEN, G STELLATO, H HYÖTY, P NIEMINEN, E VESTERINEN, J PAAVONEN
APMIS, 1992•Wiley Online LibraryCultivated CD4+ T‐helper cells from two patients with cervical adenocarcinoma showed
responses to a peptide EKTGILTVTYHSETQRTK derived from an E2 protein of human
papillomavirus type 18 (HPV 18), but not to a corresponding HPV 16 peptide (
HKSAIVTLTYDSEWQRDQ). Serum antibodies in the HPV 18 peptide were also
demonstrated in these patients. The GILT motif resembles a common pattern present in
many T‐cell epitopes, and is located at the beginning of an 11‐amino acid‐long A‐helix …
responses to a peptide EKTGILTVTYHSETQRTK derived from an E2 protein of human
papillomavirus type 18 (HPV 18), but not to a corresponding HPV 16 peptide (
HKSAIVTLTYDSEWQRDQ). Serum antibodies in the HPV 18 peptide were also
demonstrated in these patients. The GILT motif resembles a common pattern present in
many T‐cell epitopes, and is located at the beginning of an 11‐amino acid‐long A‐helix …
Cultivated CD4+ T‐helper cells from two patients with cervical adenocarcinoma showed responses to a peptide EKTGILTVTYHSETQRTK derived from an E2 protein of human papillomavirus type 18 (HPV 18), but not to a corresponding HPV 16 peptide (HKSAIVTLTYDSEWQRDQ). Serum antibodies in the HPV 18 peptide were also demonstrated in these patients. The GILT motif resembles a common pattern present in many T‐cell epitopes, and is located at the beginning of an 11‐amino acid‐long A‐helix structure close to the carboxyterminal end of HPV 18 E2. We conclude that two epitopes (a T‐helper cell epitope and a B‐cell epitope) overlap in the HPV 18 E2.
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