[HTML][HTML] DLK1-DIO3 genomic imprinted microRNA cluster at 14q32. 2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival
JM Luk, J Burchard, C Zhang, AM Liu, KF Wong… - Journal of Biological …, 2011 - ASBMB
Hepatocellular carcinoma (HCC) is a heterogeneous and highly aggressive malignancy, for
which there are no effective cures. Identification of a malignant stemlike subtype of HCC may
offer patients with a dismal prognosis a potential targeted therapy using c-MET and Wnt
pathway inhibitors. MicroRNAs (miRNAs) show promise as diagnostic and prognostic tools
for cancer detection and stratification. Using a TRE-c-Met-driven transgenic HCC mouse
model, we identified a cluster of 23 miRNAs that is encoded within the Dlk1-Gtl2 imprinted …
which there are no effective cures. Identification of a malignant stemlike subtype of HCC may
offer patients with a dismal prognosis a potential targeted therapy using c-MET and Wnt
pathway inhibitors. MicroRNAs (miRNAs) show promise as diagnostic and prognostic tools
for cancer detection and stratification. Using a TRE-c-Met-driven transgenic HCC mouse
model, we identified a cluster of 23 miRNAs that is encoded within the Dlk1-Gtl2 imprinted …