[HTML][HTML] Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent …
KMR Remen, P Henning, UH Lerner… - Journal of Biological …, 2011 - ASBMB
Bone destruction is the major pathological process in many bone metabolic diseases and is
a result of increased osteoclast formation and bone resorption. The liver X receptors (α, β),
important regulators of cholesterol metabolism and inflammatory signaling, have recently
been observed to play a role in both physiological and pathological bone turnover.
However, the relationship between liver X receptors (LXR) and osteoclast differentiation/
formation remains unknown. Here, we report that the LXR ligand GW3965 is able to clearly …
a result of increased osteoclast formation and bone resorption. The liver X receptors (α, β),
important regulators of cholesterol metabolism and inflammatory signaling, have recently
been observed to play a role in both physiological and pathological bone turnover.
However, the relationship between liver X receptors (LXR) and osteoclast differentiation/
formation remains unknown. Here, we report that the LXR ligand GW3965 is able to clearly …