Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity
N Fischel-Ghodsian, TR Prezant, WE Chaltraw… - American journal of …, 1997 - Elsevier
Purpose: Aminoglycoside-induced deafness caused by mutations in the mitochondrial 12S
ribosomal RNA gene has been described in a number of Asian patients. The purpose of the
current study is to analyze ethnically diverse patients in the United States with hearing loss
after aminoglycoside exposure for presence or absence of these mitochondrial DNA
mutations, and establish the frequency and clinical presentation associated with them.
Patients and Methods: Clinical histories, medical records, and blood samples were obtained …
ribosomal RNA gene has been described in a number of Asian patients. The purpose of the
current study is to analyze ethnically diverse patients in the United States with hearing loss
after aminoglycoside exposure for presence or absence of these mitochondrial DNA
mutations, and establish the frequency and clinical presentation associated with them.
Patients and Methods: Clinical histories, medical records, and blood samples were obtained …