[HTML][HTML] Endoplasmic reticulum stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2
A Saito, K Ochiai, S Kondo, K Tsumagari… - Journal of biological …, 2011 - ASBMB
To avoid excess accumulation of unfolded proteins in the endoplasmic reticulum (ER),
eukaryotic cells have signaling pathways from the ER to the cytosol or nucleus. These
processes are collectively termed the ER stress response. Double stranded RNA activated
protein kinase (PKR)-like endoplasmic reticulum kinase (PERK) is a major transducer of the
ER stress response and directly phosphorylates eIF2α, resulting in translational attenuation.
Phosphorylated eIF2α specifically promotes the translation of the transcription factor ATF4 …
eukaryotic cells have signaling pathways from the ER to the cytosol or nucleus. These
processes are collectively termed the ER stress response. Double stranded RNA activated
protein kinase (PKR)-like endoplasmic reticulum kinase (PERK) is a major transducer of the
ER stress response and directly phosphorylates eIF2α, resulting in translational attenuation.
Phosphorylated eIF2α specifically promotes the translation of the transcription factor ATF4 …