Lipocortin 1, a putative mediator of the anti-inflammatory actions of glucocorticoids, is
present intracellularly in a variety of tissues including human peripheral blood leukocytes.
We investigated the presence of lipocortin 1 in human leukocyte subsets using
permeabilization flow cytometry. Constitutive lipocortin 1 was detected in U937
myelomonocytic leukemia cells, and lipocortin 1 was increased by treatment with PMA or
PMA+ IFN-γ (P< 0.05) but not by dexamethasone. Lipocortin 1 was present in all leukocyte …