Eicosanoids regulate whether human and murine macrophages infected with
Mycobacterium tuberculosis die by apoptosis or necrosis. The death modality is important
since apoptosis is associated with diminished pathogen viability and should be viewed as a
form of innate immunity. Apoptotic vesicles derived from infected macrophages are also an
important source of bacterial antigens that can be acquired by dendritic cells to prime
antigen-specific T cells. This review integrates in vitro and in vivo data on how apoptosis of …