Targeted gene disruption of the prostaglandin E2 EP2 receptor
RM Breyer, CRJ Kennedy, Y Zhang, Y Guan… - Eicosanoids and Other …, 2002 - Springer
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation …, 2002•Springer
Prostaglandins comprise a diverse family of autacoids derived from cyclooxygenase (COX)
metabolism of arachidonic acid to PGG/H2, leading to the generation of five principal bio-
active prostaglandin (PG) metabolites: PGE2, PGF2a, PGD2, PGI2, and TXA2 1. The PGs
play a role in a broad range of physiologic activities including modulating inflammation,
ovulation and arterial blood pressure. These PG metabolites exert their effects at least in part
by interacting with distinct G-protein coupled receptors (GPCRs) 2, each with distinct ligand …
metabolism of arachidonic acid to PGG/H2, leading to the generation of five principal bio-
active prostaglandin (PG) metabolites: PGE2, PGF2a, PGD2, PGI2, and TXA2 1. The PGs
play a role in a broad range of physiologic activities including modulating inflammation,
ovulation and arterial blood pressure. These PG metabolites exert their effects at least in part
by interacting with distinct G-protein coupled receptors (GPCRs) 2, each with distinct ligand …
Abstract
Prostaglandins comprise a diverse family of autacoids derived from cyclooxygenase (COX) metabolism of arachidonic acid to PGG/H2, leading to the generation of five principal bio-active prostaglandin (PG) metabolites: PGE2, PGF2a, PGD2, PGI2, and TXA2 1. The PGs play a role in a broad range of physiologic activities including modulating inflammation, ovulation and arterial blood pressure. These PG metabolites exert their effects at least in part by interacting with distinct G-protein coupled receptors (GPCRs) 2, each with distinct ligand selectivity and signal transduction pathways.
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