Differences in alveolar size in inbred mouse strains
SE Soutiere, CG Tankersley, W Mitzner - Respiratory physiology & …, 2004 - Elsevier
In this paper we examined structural differences in alveolar size among inbred mouse
strains which are known to have significant differences in lung pressure–volume relations.
Accordingly, we assessed whether the relative size or number of alveoli in the C3H/HeJ,
C57BL/6J, and A/J strains are related to these lung volume differences. Lungs from each of
these strains were fixed in situ and then excised for quantitative morphometric analysis of
airspace chord lengths. Mean chord lengths (in μm) were significantly different (P< 0.0001) …
strains which are known to have significant differences in lung pressure–volume relations.
Accordingly, we assessed whether the relative size or number of alveoli in the C3H/HeJ,
C57BL/6J, and A/J strains are related to these lung volume differences. Lungs from each of
these strains were fixed in situ and then excised for quantitative morphometric analysis of
airspace chord lengths. Mean chord lengths (in μm) were significantly different (P< 0.0001) …