[HTML][HTML] Mechanisms of illness during respiratory syncytial virus infection: the lungs, the virus and the immune response

SJ Hoffman, FR Laham, FP Polack - Microbes and infection, 2004 - Elsevier
Multiple factors, including cardiopulmonary anatomy, direct viral effects and the immune
response can affect the severity of lower respiratory tract disease caused by respiratory
syncytial virus (RSV). RSV is the most frequent viral respiratory cause of hospitalization in
infants and young children in the world. In this review, we discuss the mechanisms of illness
associated with severe RSV lower respiratory tract disease. A better understanding of the
factors affecting the course of illness and their interplay should allow development of …