[PDF][PDF] Further checkpoints in Th1 development
DS Robinson, A O'Garra - Immunity, 2002 - cell.com
DS Robinson, A O'Garra
Immunity, 2002•cell.comTight control of Th1 immunity is essential to prevent immunopathology. Central to control of
the IFN-γ gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is
dominant in directing Th1 development, while synergizing with IL-18 for IFNγ production
from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in
synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-
1. We review the coordination of these checkpoints in Th1 development and function.
the IFN-γ gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is
dominant in directing Th1 development, while synergizing with IL-18 for IFNγ production
from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in
synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-
1. We review the coordination of these checkpoints in Th1 development and function.
Abstract
Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-γ gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNγ production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.
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