[HTML][HTML] Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte …
H Hirokane, M Nakahara, S Tachibana… - Journal of Biological …, 2004 - ASBMB
Microsomal triglyceride transfer protein (MTP) is involved in the transfer of triglycerides,
cholesterol esters, and phospholipids to newly synthesized apolipoprotein (apo) B. It is
therefore essential for lipoprotein synthesis and secretion in the liver and the small intestine.
Although several recent experiments have revealed the transcriptional regulation of the MTP
gene, little has been revealed to date about hepatocyte nuclear factor-4 (HNF-4)-dependent
regulation. We here report that the human MTP gene promoter contains a pair of functional …
cholesterol esters, and phospholipids to newly synthesized apolipoprotein (apo) B. It is
therefore essential for lipoprotein synthesis and secretion in the liver and the small intestine.
Although several recent experiments have revealed the transcriptional regulation of the MTP
gene, little has been revealed to date about hepatocyte nuclear factor-4 (HNF-4)-dependent
regulation. We here report that the human MTP gene promoter contains a pair of functional …