Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and …
A Hattoum, E Rubin, A Orr, GK Michalopoulos - Human Pathology, 2013 - Elsevier
Liver regeneration under normal circumstances proceeds through proliferation of all cellular
elements of the liver. Studies with rodent models have shown that when proliferation of
hepatocytes is inhibited, progenitor cells arising from the biliary compartment
transdifferentiate into “oval/progenitor” cells, which proceed to differentiate into hepatocytes.
Recent studies have shown that the same pathways may operate in human liver failure. The
growth factor receptors (HGF [hepatocyte growth factor] receptor) and epidermal growth …
elements of the liver. Studies with rodent models have shown that when proliferation of
hepatocytes is inhibited, progenitor cells arising from the biliary compartment
transdifferentiate into “oval/progenitor” cells, which proceed to differentiate into hepatocytes.
Recent studies have shown that the same pathways may operate in human liver failure. The
growth factor receptors (HGF [hepatocyte growth factor] receptor) and epidermal growth …