Trefoil factors: initiators of mucosal healing

D Taupin, DK Podolsky - Nature reviews Molecular cell biology, 2003 - nature.com
D Taupin, DK Podolsky
Nature reviews Molecular cell biology, 2003nature.com
Maintaining the integrity of the gastrointestinal tract, despite the continual presence of
microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of
small, yet abundant, secreted proteins—the trefoil factors (TFFs). TFFs protect mucous
epithelia from a range of insults and contribute to mucosal repair, although the signalling
events that mediate these responses are only partially understood.
Abstract
Maintaining the integrity of the gastrointestinal tract, despite the continual presence of microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of small, yet abundant, secreted proteins — the trefoil factors (TFFs). TFFs protect mucous epithelia from a range of insults and contribute to mucosal repair, although the signalling events that mediate these responses are only partially understood.
nature.com