[HTML][HTML] Plasma IL-25 is elevated in a subgroup of patients with clinical reactivity to peanut
JA Aalberse, AO van Thuijl, Y Meijer… - Clinical and …, 2013 - Springer
JA Aalberse, AO van Thuijl, Y Meijer, W de Jager, T van der Palen-Merkus, AB Sprikkelman…
Clinical and Translational Allergy, 2013•SpringerBackground One of the IL-17 family members, IL-25, has been implicated with the initiation
and amplification of Th2 responses in animal models and has been associated with airway
hyper-reactivity. The involvement of IL-25 and also IL-17 in food allergic disease remains to
be investigated. Findings In this study thirty children suspected of peanut allergic disease
underwent a double-blind placebo controlled food challenge (DBPCFC) and IL-25 and IL-17
plasma levels were determined before and after challenge. IL-25 was highly elevated only in …
and amplification of Th2 responses in animal models and has been associated with airway
hyper-reactivity. The involvement of IL-25 and also IL-17 in food allergic disease remains to
be investigated. Findings In this study thirty children suspected of peanut allergic disease
underwent a double-blind placebo controlled food challenge (DBPCFC) and IL-25 and IL-17
plasma levels were determined before and after challenge. IL-25 was highly elevated only in …
Background
One of the IL-17 family members, IL-25, has been implicated with the initiation and amplification of Th2 responses in animal models and has been associated with airway hyper-reactivity. The involvement of IL-25 and also IL-17 in food allergic disease remains to be investigated.
Findings
In this study thirty children suspected of peanut allergic disease underwent a double-blind placebo controlled food challenge (DBPCFC) and IL-25 and IL-17 plasma levels were determined before and after challenge. IL-25 was highly elevated only in subgroup of children with a positive DBPCFC outcome. Plasma IL-25 was absent in children with a negative DBPCFC outcome and in healthy controls.
Conclusions
This study shows that IL-25, an IL-17 family member, is highly elevated only in children with a clinical response to peanut. This suggests a role for IL-25 in the pathogenesis of peanut allergy and elevated plasma IL-25 may be a sign of a severe atopic phenotype.
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