New insights of T cells in the pathogenesis of psoriasis

Y Cai, C Fleming, J Yan - Cellular & molecular immunology, 2012 - nature.com
Y Cai, C Fleming, J Yan
Cellular & molecular immunology, 2012nature.com
Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases
characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells,
macrophages and neutrophils. Although the pathogenesis of psoriasis is not fully
understood, there is ample evidence suggesting that the dysregulation of immune cells in
the skin, particularly T cells, plays a critical role in psoriasis development. In this review, we
mainly focus on the pathogenic T cells and discuss how these T cells are activated and …
Abstract
Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages and neutrophils. Although the pathogenesis of psoriasis is not fully understood, there is ample evidence suggesting that the dysregulation of immune cells in the skin, particularly T cells, plays a critical role in psoriasis development. In this review, we mainly focus on the pathogenic T cells and discuss how these T cells are activated and involved in the disease pathogenesis. Newly identified ‘professional’IL-17-producing dermal γδ T cells and their potential role in psoriasis will also be included. Finally, we will briefly summarize the recent progress on the T cell and its related cytokine-targeted therapy for psoriasis treatment.
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