[PDF][PDF] The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance

RV Farese, R Zechner, CB Newgard, TC Walther - Cell metabolism, 2012 - cell.com
RV Farese, R Zechner, CB Newgard, TC Walther
Cell metabolism, 2012cell.com
Excessive deposition of fat in the liver (hepatic steatosis) is frequently accompanied by
hepatic insulin resistance. Whether this correlation is due to a causal relationship between
the conditions has been the subject of considerable debate, and the literature abounds with
conflicting data and theories. Here we provide a perspective by defining the problem and its
challenges, analyzing the possible causative relationships, and drawing some conclusions.
Excessive deposition of fat in the liver (hepatic steatosis) is frequently accompanied by hepatic insulin resistance. Whether this correlation is due to a causal relationship between the conditions has been the subject of considerable debate, and the literature abounds with conflicting data and theories. Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions.
cell.com