NFATc1 in inflammatory and musculoskeletal conditions
AO Aliprantis, LH Glimcher - … : Interactions of the Immune and skeletal …, 2010 - Springer
AO Aliprantis, LH Glimcher
Osteoimmunology: Interactions of the Immune and skeletal systems II, 2010•SpringerThe nuclear factor of activated T-cells (NFAT) family of transcription factors specify
developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to
multiple seemingly unrelated biologic processes, including heart valve formation, T-cell
activation, osteoclast development, and the mitigation of hair follicle stem cell proliferation.
Here, we review how our recently generated NFATc1 conditional knockout mouse has
contributed to our understanding of this transcription factor in inflammatory and …
developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to
multiple seemingly unrelated biologic processes, including heart valve formation, T-cell
activation, osteoclast development, and the mitigation of hair follicle stem cell proliferation.
Here, we review how our recently generated NFATc1 conditional knockout mouse has
contributed to our understanding of this transcription factor in inflammatory and …
Abstract
The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell proliferation. Here, we review how our recently generated NFATc1 conditional knockout mouse has contributed to our understanding of this transcription factor in inflammatory and musculoskeletal conditions and their treatment.
Springer