Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG) have been strongly
associated with atopic dermatitis and allergic phenotypes in multiple populations. The role of
these mutations in the development of asthma is less clear, particularly in patients who do
not have coincident atopic dermatitis. OBJECTIVE: To determine whether FLG mutations are
associated with asthma or asthma-related intermediate phenotypes. METHODS: We
genotyped 2 loss-of-function FLG mutations (R501X and 2282del4) in white children (age 5 …
associated with atopic dermatitis and allergic phenotypes in multiple populations. The role of
these mutations in the development of asthma is less clear, particularly in patients who do
not have coincident atopic dermatitis. OBJECTIVE: To determine whether FLG mutations are
associated with asthma or asthma-related intermediate phenotypes. METHODS: We
genotyped 2 loss-of-function FLG mutations (R501X and 2282del4) in white children (age 5 …