Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems
JM Gottwein, J Bukh - Advances in virus research, 2008 - Elsevier
Worldwide∼ 180 million people are chronically infected with hepatitis C virus (HCV). HCV
isolates exhibit extensive genetic heterogeneity and have been grouped in six genotypes
and various subtypes. Additionally, several naturally occurring intergenotypic recombinants
have been described. Research on the viral life cycle, efficient therapeutics, and a vaccine
has been hampered by the absence of suitable cell culture systems. The first system
permitting studies of the full viral life cycle was intrahepatic transfection of RNA transcripts of …
isolates exhibit extensive genetic heterogeneity and have been grouped in six genotypes
and various subtypes. Additionally, several naturally occurring intergenotypic recombinants
have been described. Research on the viral life cycle, efficient therapeutics, and a vaccine
has been hampered by the absence of suitable cell culture systems. The first system
permitting studies of the full viral life cycle was intrahepatic transfection of RNA transcripts of …