In vitro veritas? The challenges of studying hepatitis C virus infectivity in a test tube
T von Hahn, JA McKeating - Journal of hepatology, 2007 - journal-of-hepatology.eu
Widely known as a worldwide leading cause of chronic hepatitis, cirrhosis and
hepatocellular carcinoma, hepatitis C virus (HCV) has also acquired some notoriety among
virologists for being a difficult pathogen to study. Accordingly, the mechanisms by which
hepatitis C virus (HCV) enters and infects host cells are incompletely understood. Numerous
cell surface molecules, including the tetraspanin CD81, scavenger receptor BI (SR-BI) and
low-density lipoprotein receptor (LDLR), have been put forward as potential HCV (co-) …
hepatocellular carcinoma, hepatitis C virus (HCV) has also acquired some notoriety among
virologists for being a difficult pathogen to study. Accordingly, the mechanisms by which
hepatitis C virus (HCV) enters and infects host cells are incompletely understood. Numerous
cell surface molecules, including the tetraspanin CD81, scavenger receptor BI (SR-BI) and
low-density lipoprotein receptor (LDLR), have been put forward as potential HCV (co-) …